TABLE 2.
Induction Toxicity | Ethnicity | p-value | |||||
---|---|---|---|---|---|---|---|
Entire Cohort | Hispanic | Non-Hispanic | |||||
| |||||||
No. | % | No. | % | No. | % | ||
All | 730 | - | 150 | - | 580 | - | - |
| |||||||
Infection | 203 | 28 | 37 | 25 | 166 | 29 | 0.36 |
Bacterial | 183 | 25 | 29 | 19 | 154 | 27 | 0.07 |
Fungal | 30 | 4 | 8 | 5 | 22 | 4 | 0.36 |
Viral | 5 | <1 | 1 | 1 | 4 | 1 | 1.00 |
Opportunistic | 3 | <1 | 1 | 1 | 2 | 0 | - |
| |||||||
Asparaginase toxicity | 47 | 6 | 10 | 7 | 37 | 6 | 0.85 |
Pancreatitis | 17 | 2 | 6 | 4 | 11 | 2 | 0.13 |
Allergy | 10 | 1 | 2 | 1 | 8 | 1 | 1.00 |
Thrombosis | 20 | 3 | 2 | 1 | 18 | 3 | 0.40 |
| |||||||
Bone Event | 3 | <1 | 3 | 1 | 0 | 0 | - |
Bone Fracture | 3 | <1 | 3 | 1 | 0 | 0 | - |
Osteonecrosis | 0 | <1 | 0 | 0 | 0 | 0 | - |
| |||||||
Post-Induction Toxicity | Ethnicity | p-value | |||||
Entire Cohort | Hispanic | Non-Hispanic | |||||
| |||||||
No. | % | No. | % | No. | % | ||
| |||||||
All | 690 | - | 140 | - | 550 | - | - |
| |||||||
Infection | 220 | 32 | 44 | 31 | 176 | 32 | 0.92 |
Bacterial | 158 | 23 | 30 | 21 | 128 | 23 | 0.74 |
Fungal | 17 | 2 | 2 | 1 | 15 | 3 | 0.55 |
Viral | 59 | 9 | 17 | 12 | 42 | 8 | 0.09 |
Opportunistic | 21 | 3 | 1 | 1 | 20 | 4 | 0.10 |
| |||||||
Asparaginase toxicity | 183 | 27 | 40 | 29 | 143 | 26 | 0.59 |
Pancreatitis | 75 | 11 | 20 | 14 | 55 | 10 | 0.17 |
Allergy | 63 | 9 | 14 | 10 | 49 | 9 | 0.74 |
Thrombosis | 72 | 10 | 11 | 8 | 61 | 11 | 0.35 |
| |||||||
Bone Event* | 163 | 24 | 15 | 11 | 148 | 27 | <0.0001 |
Bone Fracture | 131 | 19 | 11 | 8 | 120 | 22 | <0.0001 |
Osteonecrosis | 54 | 8 | 4 | 3 | 50 | 9 | 0.013 |
Only includes bone toxicity on therapy