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The mechanism by which autophagy controls activation of the inflammasome. Inflammasome sensors such as AIM2 and adaptor molecule ASC are ubiquitinated then targeted for degradation by autophagy. Similarly, the production of pro-IL-1β is regulated by autophagy. On the other hand, active IL-1β and IL-18 may exploit the autophagy machinery for packaging and release to extracellular milieu.
