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. 2018 Jan 12;8:627. doi: 10.1038/s41598-017-18974-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of mutational spectra induced by retroviral RTs during RNA- and DNA-dependent DNA synthesis. (Up) Combined mutational spectra derived from RNA-dependent DNA synthesis reactions including all RTs analysed in this study (Supplementary Figs S2 to S7). RTs included are those of WT HIV-1_BH10 (pink), HIV-1_ESP49 (purple), AMV (red), and MLV (green), and mutants O_K65R/V75I (blue) and O_K65R (brown). (Bottom) Combined mutational spectra induced during DNA-dependent DNA synthesis reactions, and taken from previously published reports^15,18,36. RT colour codes are the same as above. For all RTs and mutational spectra, single-nucleotide substitutions are indicated by the letter corresponding to the new base above the template sequence of the lacZα target. Open upright triangles represent insertions and inverted triangles indicate deletions. The triangles are positioned at the 3′ end of the frameshift, with the number of inserted/deleted nucleotides indicated between parentheses. If not specified, one-nucleotide insertions correspond to the duplication of the base where the triangle is positioned.