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. 2018 Jan 12;8:670. doi: 10.1038/s41598-017-18428-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TNF-α/IFN-γ-Induced Human Placental-Derived ASCs Inhibit Tumor Cell Proliferation and Vascularization in MDA-MB-231 Tumors in Nude Mice. (a) Representative section of H&E-stained MDA-MB-231 mammary fat pad tumor with grade 2 necrosis from mouse treated with TNF-α/IFN-γ-induced placental-derived ASCs. “N” marks areas of necrosis. (b) Mean necrosis grade in MDA-MB-231 mammary fat pad tumors from nude mice treated with either induced-ASCs or vehicle. (c) Mean percentage of proliferating cells in MDA-MB-231 mammary fat pad tumors from nude mice treated with either induced-ASCs or vehicle. (d) Representative sections of CD34 immunostained MDA-MB-231 mammary fat pad tumors showing different levels of vascularization all from different areas of tumors from mice treated with induced-ASCs. (e) Mean area occupied by blood vessels in MDA-MB-231 mammary fat pad tumors from nude mice treated with either induced-ASCs or vehicle. (f) Mean active caspase 3-expressing cells per field in MDA-MB-231 mammary fat pad tumors from nude mice treated with either induced-ASCs or vehicle. (g) Correlation between percent CD34+ stained area and percent Ki67+ cells in MDA-MB-231 mammary fat pad tumors in nude mice. n = 10. Error bars are SEM. P-values are based on a one-tailed student’s t-test.