Table 1.
Concentration of Cytokines in the Conditioned Medium of Non-Induced and TNF-α/IFN-γ-Induced Human Placental-Derived ASCs.
| Cytokine | Non-Induced ASC | Induced ASC | p value |
|---|---|---|---|
| MMP-1 | 24,993 ± 8267 | 95,800 ± 23,208 | n.s. |
| sICAM-1 | 1379 ± 108 | 33,983 ± 5862 | <0.01 |
| CXCL9 | <445 * | 9138 ± 1534 | <0.01 |
| Angiopoietin-1 | 3392 ± 608 | 2821 ± 409 | n.s. |
| CCL5 | 4 ± 1 | 2467 ± 431 | <0.01 |
| CXCL8 | 204 ± 45 | 2111 ± 819 | n.s. |
| MMP-12 | 1371 ± 191 | 1358 ± 134 | n.s. |
| IL-6 | 700 ± 401 | 1255 ± 331 | n.s. |
| VEGF | 871 ± 108 | 1024 ± 54 | n.s. |
| CXCL11 | <4* | 612 ± 70 | <0.001 |
| sFAS | 363 ± 36 | 567 ± 45 | <0.05 |
| OPN | 892 ± 645 | 451 ± 176 | n.s. |
| G-CSF | <30* | 279 ± 125** | n.s. |
| TGF-β1 | 315 ± 75 | 302 ± 34 | n.s. |
| Adiponectin | <70*** | 230 ± 35 | <0.05 |
| IL-31 | <26 ± 9⁑ | 124 ± 21 | <0.05 |
| IFN-γ | <14* | 42 ± 7 | <0.01 |
| TGF-β2 | 45 ± 19 | 39 ± 4 | n.s. |
| II-17A | 27 ± 6 | 38 ± 3 | n.s. |
| IL-18 | <14* | 28 ± 4 | <0.05 |
| IL-12p70 | <7* | 15 ± 3 | n.s. |
| IL-10 | <2* | 13 ± 2 | <0.01 |
| FLT3L | <10* | 12 ± 1 | <0.01 |
| IL-1β | <2† | 7 ± 2 | <0.05 |
Units of concentrations are pg/mL. *Lower limit of quantification (LLOQ), **one data point < LLOQ, ***one data point > LLOQ of 53 pg/mL, ⁑one data point < LLOQ of 14 pg/mL, †one data point > LLOQ of 2 pg/mL, n.s. = not statistically significant, n = 3 for non-induced-ASC, n = 6 for induced-ASC. Names of cytokines that are significantly upregulated are in bold.