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. 2018 Jan 12;8:607. doi: 10.1038/s41598-017-18747-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacology of 4-AP derivatives. (A) Pharmacological parameters for 4-AP derivatives and control compounds. cLogP: predicted logP value from SciFinder calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02. logD: experimental partition coefficient octanol:water at pH 7.4 (n = 3). P_e: permeability coefficient across artificial membrane (n = 3). t_{1/2(microsomes)}: half-life in mouse microsomes (n = 3). (B) In vivo effects after intraperitoneal injection of 4-AP derivatives (200 μL/200 g mouse).