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. 2018 Jan 12;8:607. doi: 10.1038/s41598-017-18747-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of demyelination by PET and confirmation by autoradiography and histochemical staining. (A) Representative coronal fused PET/CT images of the cerebellum of injected rats. Sprague Dawley rats received 0.15–0.30 μCi/g of [¹⁸F]3-F-4-AP via tail vein injection. PET/CT images were acquired 0 to 25 min post injection. Dashed circle represents region of interest. (B) Quantification of the SUV of the lesioned and control regions of interest. There is significant increase in SUV on the on the LPC-injected animals (P = 0.0063) but not on the saline-injected animals. (C) Representative ex vivo autoradiography and LFB staining of LPC injected rat. (Scale bar: 4 mm). There is high correlation between PET, autoradiography and LFB staining.