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. 2018 Jan 12;8:672. doi: 10.1038/s41598-017-18781-1

Table 3.

ZIKV Env peptide relative binding affinity to HLA-DR molecules.

Env peptide DR1 DR3 DR4 DR7 DR11 DR15 DRB5
p1 [1–20] 638 8 118 86 >2 248 175 474
p14 [131–150] 1 250 0.2 7 0.4 0.2 1
p31 [301–320] 3 >1 129 11 1 50 53 2
p41 [401–420] 900 >1 129 114 >359 4 75 65
p42 [411–430] 319 19 >477 119 5 125 54

Data were expressed as relative affinity: ratio of the half maximal inhibitory concentration of the peptide to the half maximal inhibitory concentration of the reference peptide. The peptide concentration preventing 50% binding of labeled peptide (IC50) was evaluated and data expressed as relative affinity: the ratio of the IC50 of test peptide to the IC50 of reference peptide. Mean ± SEM was calculated from two to three independent experiments. Relative affinities of 10 or less were considered high binders, and relative affinities of 10–100 were moderate binders.