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. 2018 Jan 12;8:629. doi: 10.1038/s41598-017-19035-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional activity of ETnI, ETnII-α, ETnII-β, ETnII-γ, IAP and MusD genes in whole embryos and, from the offspring, in blood and brain samples obtained from VPA- and vehicle-treated CD-1 mice. The ERVs expression profile in whole embryos (panel A–F) explanted 3 and 24 hours post the treatment, in blood (panel A’–F’) and brain (panel A”–F”) samples obtained at post natal day 1, 7, 23 and 120, was examined by real time-PCR and represented as box plots, depicting mild (black dot) and extreme (asterisk) outliers for each group. In whole embryos higher transcriptional activity of all ERVs analysed in VPA groups (blue box plots) than in vehicle groups (white box plots) was evident, at both time points. In blood, VPA-treated mice (blue box plots) showed higher transcriptional levels of all ERVs than in age-matched controls (white box plots), at post natal day 1 and 7, while in brain at each age points.