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. 2018 Jan 12;8:633. doi: 10.1038/s41598-017-19123-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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⁶⁴Cu-pembrolizumab tracer uptake in NSG/293 T/hPD-1 from ROI and ex vivo biodistribution measurements. (a) Region of interest (ROI) quantification of immunoPET tracer signal (mean ± SD % ID/g) from the xenograft of NSG mice, NSG/293 T/hPD-1-blk (blocking: n = 4) and NSG/293 T/hPD-1-nblk (non-blocking: n = 4), after 4 24, and 48 h post-injection, * indicates p < 0.001. (b) Xenograft-to-muscle background ratios (XMR) were computed from ROIs at 24 and 48 h p.i. The XMR in NSG/293 T/hPD-1-nblk mice were significantly greater than in NSG/293 T/hPD-1-blk mice, p = 0.001. (c) Biodistribution profiles of immunoPET tracer in NSG/293 T/hPD-1-blk and NSG/293 T/hPD-1-nblk mice were compared after 48 h microPET-CT scans. Tracer uptake in each tissue was computed as mean ± standard deviation % ID/g (decay-corrected). Unpaired two-tailed Student’s t test was used to compare mean values between groups.