Table 1.
COMT SNPs (single nucleotide polymorphisms) on suicidal phenotypes. Single marker association analyses (SNPs: rs4633, rs4680, rs737865, rs6269, rs165599). Significant p-values in bold. False discovery rate (FDR) p-values after multiple testing correction in brackets. [HW = Hardy-Weinberg equilibrium, COMT = Catechol-O-methyltransferase, NSSI = non-suicidal self-injury, total = total sample].
HW p-value: 0,45 | total | female | male | |||
---|---|---|---|---|---|---|
χ2 | p-value | χ2 | p-value | χ2 | p-value | |
rs4633 | ||||||
transient thought | 1.532 | 0.465 | 0.041 | 0.98 | 2.044 | 0.36 |
concrete thought | 1.1 | 0.577 | 1.881 | 0.39 | 1.346 | 0.51 |
NSSI | 3.785 | 0.151 | 3.09 | 0.213 | 0.679 | 0.712 |
self-harm | 2.519 | 0.284 | 5.15 | 0.076 | 0.256 | 0.88 |
suicide attempt | 0.929 | 0.628 | 0.714 | 0.7 | 0.169 | 0.919 |
rs4680 | ||||||
transient thought | 1.31 | 0.519 | 0.041 | 0.98 | 1.575 | 0.455 |
concrete thought | 1.213 | 0.545 | 1.881 | 0.39 | 1.777 | 0.411 |
NSSI | 4.047 | 0.132 | 3.09 | 0.213 | 1.863 | 0.394 |
self-harm | 1.88 | 0.391 | 5.15 | 0.076 | 0.893 | 0.64 |
suicide attempt | 0.502 | 0.778 | 0.714 | 0.7 | 0.015 | 0.993 |
HW p-value: 0,46 | total | female | male | |||
χ2 | p-value | χ 2 | p-value | χ 2 | p-value | |
rs737865 | ||||||
transient thought | 0.248 | 0.883 | 0.357 | 0.836 | 0.113 | 0.945 |
concrete thought | 5.17 | 0.075 | 2.687 | 0.26 | 2.639 | 0.267 |
NSSI | 1.422 | 0.491 | 2.956 | 0.228 | 0.267 | 0.875 |
self-harm | 0.431 | 0.806 | 2.187 | 0.335 | 4.72 | 0.94 |
suicide attempt | 6.08 | 0.048 | 1.12 | 0.57 | 10.1 | 0.006 [0.030] |
HW p-value: 0,8 | total | female | male | |||
χ 2 | p-value | χ 2 | p-value | χ 2 | p-value | |
rs6269 | ||||||
transient thought | 0.965 | 0.617 | 1.034 | 0.596 | 2.391 | 0.302 |
concrete thought | 8.085 | 0.018 [0.09] | 5.549 | 0.062 | 2.943 | 0.23 |
NSSI | 2.635 | 0.268 | 1.948 | 0.378 | 0.392 | 0.822 |
self-harm | 1.986 | 0.37 | 2.218 | 0.33 | 1.599 | 0.45 |
suicide attempt | 2.383 | 0.304 | 0.311 | 0.856 | 3.784 | 0.151 |
HW p-value: 0,55 | total | female | male | |||
χ 2 | p-value | χ 2 | p-value | χ 2 | p-value | |
rs165599 | ||||||
transient thought | 2.296 | 0.317 | 0.438 | 0.803 | 5.625 | 0.06 |
concrete thought | 3.018 | 0.221 | 0.08 | 0.961 | 7.722 | 0.021 [0.1] |
non-suicidal self-mutilation | 3.256 | 0.196 | 0.955 | 0.622 | 2.265 | 0.322 |
self-harm | 1.881 | 0.39 | 3.21 | 0.201 | 0.118 | 0.943 |
suicide attempt | 1.027 | 0.598 | 0.619 | 0.734 | 2.277 | 0.32 |