Table 3.
Haplotypic association analyses with suicidal phenotypes as dependent variables (suicide attempt, self-harm, NSSI = non-suicidal self-injury). Haplotypes: 3- and 4-marker slide windows of COMT SNPs rs 737865, rs6269, rs4633, rs9332377, rs165599. Significant p-values in bold. False discovery rate (FDR) p-values after multiple testing correction in brackets.
| Haplotypes: 3-marker slide windows | 4-marker slide windows | ||||||
|---|---|---|---|---|---|---|---|
| a) suicide attempt | |||||||
| rs737865 | G | G | |||||
| rs6269 | A | A | A | A | |||
| rs4633 | T | C | C | T | C | C | |
| rs4680 | G | G | G | A | G | G | |
| rs9332377 | C | C | C | C | |||
| rs165599 | G | G | |||||
| Global p | 0.031 [0.124] | 0.37 | 0.4 | 0.62 | 0.05 [0.22] | 0.47 | 0.54 |
| Individual p | 0.003 [0.021] | 0.34 | 0.18 | 0.31 | 0.009 [0.045] | 0.23 | 0.24 |
| Frequency cases/contr | 0.025/0.08 | 0.08/0.05 | 0.35/0.28 | 0.11/0.08 | 0.02/0.07 | 0.08/0.05 | 0.11/0.08 |
| b) self-harm | |||||||
| rs737865 | G | G | |||||
| rs6269 | A | A | A | A | |||
| rs4633 | T | T | T | T | T | T | |
| rs4680 | A | A | A | A | A | A | |
| rs9332377 | T | C | C | C | |||
| rs165599 | A | A | |||||
| Global p | 0.1 | 0.25 | 0.15 | 0.34 | 0.18 | 0.24 | 0.29 |
| Individual p | 0.02 [0.08] | 0.11 | 0.11 | 0.11 | 0.052 | 0.15 | 0.1 |
| Frequency cases/contr | 0.02/0.09 | 0.48/0.56 | 0/0.01 | 0.44/0.52 | 0.02/0.08 | 0.48/0.55 | 0.44/0.52 |
| c) NSSI | |||||||
| rs737865 | G | G | |||||
| rs6269 | A | A | G | G | |||
| rs4633 | T | T | C | C | C | C | |
| rs4680 | G | G | C | G | G | G | |
| rs9332377 | T | T | T | T | |||
| rs165599 | G | G | |||||
| Global p | 0.1 | 0.11 | 0.02 [0.92] | 0.1 | 0.08 | 0.03 | 0.04 |
| Individual p | 0.03 [0.08] | 0.04 [0.08] | 0.03 [0.08] | 0.03 [0.08] | 0.06 | 0.03 [0.1] | 0.03 [0.1] |
| Frequency cases/contr | 0.03/0.09 | 0/0.01 | 0.17/0.08 | 0.17/0.08 | 0.27/0.17 | 0.17/0.08 | 0.17/0.08 |