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. 2018 Jan 12;8:679. doi: 10.1038/s41598-017-19068-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of inorganic nickel magnetic material in murine organs after 2-week exposure to nanomaterials (n = 3 animals). Comparison of total mass of nickel nanomaterial measured accumulated in each organ versus organ mass. Inorganic nickel content was measured by SQUID magnetometry as total amount of magnetic signal compared to vehicle. Data are shown as average ± standard error of the mean (n_repeats = 3). The symbols (*), (**) and (***) indicate statistical significant changes as compared to the values measured against negative control samples (p < 0.05, 0.01 and 0.001, respectively) (two-way ANOVA and Bonferroni post-test).