Table 4.

The differential metabolites in SMMC-7721 cell and medium after treatment of CKI. *p < 0.05, **p < 0.01, ***p < 0.001 versus untreated cells.

No	Metabolites	CKI cell	fold change	CKI medium	fold change
1	Leucine	↑**	4.00	↓***	1.97
2	Valine	↑**	5.39	↓***	1.60
3	Acetate	↑***	4.81
4	Lactate			↓***	5.25
5	Pyruvate			↑***	4.91
6	Succinate			↑***	2.17
7	Pyroglutamate			↑***	2.29
8	Glutamate	↓***	2.98
9	Glutamine	↑**	1.52
10	Glutathione	↓***	4.10
11	Creatine	↓**	2.61
12	GPCc	↓**	2.57
13	Glycine	↓***	2.91	↑***	1.67
14	Threonine			↑***	12.76
15	1,3-Dihydroxyacetone	↓**	2.01
16	Glycerol	↑***	2.31	↑**	2.08
17	Alanine			↑***	1.32
18	Adenosine monophosphate	↓*	1.52
19	β-Glucose	↑**	11.05
20	Tyrosine	↑***	3.69
21	Phenylalanine	↑***	3.34
22	Hypoxanthine	↓***	3.18