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. 2018 Jan 8;8:1872. doi: 10.3389/fimmu.2017.01872

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Copyright © 2018 Olafsdottir, Alexandersson, Sveinbjornsson, Lapini, Palladino, Montomoli, Del Giudice, Gudbjartsson and Jonsdottir.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Strong association between age and both hemagglutination inhibition (HAI) and neutralization post-vaccination titer and seroprotection rate. Log HAI titer at different age gaps for all three serotypes (A). HAI seroprotection rate (HAI > 40) pre- and post-vaccination at different age gaps (B). Log microneutralization (MN) titer at different age gaps for H1N1 strain (C). Indicative MN seroprotection rate for H1N1 (MN > 20) pre- and post-vaccination at different age gaps (D). Line within the boxplots in (A,C) indicate median value and the top and the bottom correspond to the 25th (Q1) and 75th (Q3) quantiles. The whiskers of the box plots are located at Q1 − 1.5 interquartile range (IQR) and Q3 + 1.5 IQR. P-values for association between post-vaccination titer and age (A,C) and seroprotection rate and age (B,D) are shown. Pre-titer, age, measurement date, previous influenza vaccination status, and gender were included as covariates.