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Longitudinal analysis of all prespecified PROs symptoms of interest: cough, dyspnea, and pain by mutation type (Del19 and L858R). Scores range from 0 to 100 (100 is equivalent to the highest burden of symptoms and 0 to the lowest burden); mean treatment difference shown as afatinib minus chemotherapy and, as such, a negative score favors afatinib treatment. CI, confidence interval; PRO, patient-reported outcome
