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. 2017 Oct 23;33(2):485–514. doi: 10.1007/s12640-017-9818-6

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Tetrahydroisoquinolines capable of crossing the blood–brain barrier: a 1,2,3,4-tetrahydroisoquinoline, b 5,6,7,8-tetrahydroisoquinoline, c 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, d 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, e 1-methyl-1,2,3,4-tetrahydroisoquinoline, f 1-benzyl-1,2,3,4-tetrahydroisoquinoline, shown for structural comparison (ChemDraw Professional 16.0, PerkinElmer Informatics, Inc.)