Table 5.
Results of GLM analyses with the six immune biomarkers, i.e., interleukin-1α, soluble interleukin 1 receptor antagonist (sIL-1RA), sIL-2R, sIL-6R, soluble tumor necrosis factor receptor 60 kDa/80 kDa (sTNF-R1/R2), and thiobarbituric acid reactive substances (TBARS) as dependent variables and diagnostic groups, age, gender, marital status, and nicotine dependence as explanatory variables
| Tests | Dependent variables | Explanatory variables | F | df | p |
|---|---|---|---|---|---|
| Multivariate analysis in all subjects | 7 biomarkers | Current, no-current Age Sex TUD PC1 PC2 |
2.74 1.76 0.92 2.48 1.59 0.98 |
14/208 7/103 7/103 7/103 7/103 7/103 |
0.001 0.103 0.497 0.022 0.148 0.447 |
| Between-subject analyses | sIL-1RA sIL-6R TBARS |
HC, current, no-current HC, current, no-current HC, current, no-current |
4.19 4.68 8.10 |
2/109 2/109 2/109 |
0.018 0.011 0.001 |
| Multivariate analysis in all subjects | 7 biomarkers | HC, atypical, no atypical | 2.96 | 14/242 | < 0.001 |
| Multivariate analysis in all subjects | 7 biomarkers | HC, MEL, no MEL | 2.94 | 14/242 | < 0.001 |
| Multivariate analysis in depressed subjects | 7 biomarkers | HDRS MADRS Number episodes Age at onset PC1 PC2 |
0.80 0.49 0.59 1.56 1.53 0.64 |
7/81 7/81 7/76 7/80 7/65 7/65 |
0.598 0.840 0.764 0.160 0.174 0.725 |
HC, current, non-current: diagnostic groups are entered as three groups, healthy controls (HC), current depression, and no-current depression