Figure 6.

The effects of disease-associated mutations on the formation of the KANK1·KIF21A complex. A, the combined ribbon and stick-dot representations showing the detailed roles of disease-causing mutations in KANK1 ANK and KIF21A KBD. In this drawing, the side chains of key residues associated with diseases are shown in the stick mode, and the related hydrogen bonds and salt bridges are indicated by black dashed lines. B, effects of various disease-associated mutations on KANK1·KIF21A complex formation based on ITC assays. n.d., not detectable.