Figure 8.

Jnk2^−/− mice are protected from hypoxia-induced pulmonary hypertension. A, right ventricular systolic pressure measurements in WT or Jnk2^−/− mice kept in normoxic conditions (21% oxygen) or chronic hypoxic conditions (10% oxygen) for 21 days. n = 8 in WT control group, n = 8 in Jnk2^−/− control group, n = 7 in WT hypoxia group, and n = 7 in Jnk2^−/− hypoxia group. B, red blood cell count in the peripheral blood of WT or Jnk2^−/− mice kept at 10% oxygen for 21 days. n = 5 in each group. All data are presented as mean ± S.E. (error bars). Statistical significance was determined in A by one-way ANOVA with Tukey's post hoc test and in B by a t test (*, p ≤ 0.05; ****, p ≤ 0.0001; ns, non-significant for the comparisons indicated by brackets).