Figure 6.

Effects of hippocampal RAGEab injection in prefrontal cortex RAGE and markers of neuroinflammation and neurodegeneration in animals submitted to CLP. RAGEab was administered bilaterally into the hippocampus at 100 μg/kg at days 15, 17, and 19 after CLP. Control animals received 100 μg/kg of isotype IgG. At day 30 after CLP, the prefrontal cortex was prepared for immunofluorescence detection of RAGE (A), Iba-1 (B), GFAP (C), Aβ (D), and phospho-Tau (E). DAPI was used for nuclear staining. Magnification bar length is 100 μm.