Table 1.
Values of fluorescence immunostaining intensity (fold-induction)
Mean ± S.D. values of fluorescence intensity units from eight animals per group. ****, p < 0.0001, ***, p < 0.001, and **, p < 0.01 were compared with sham group. ####, p < 0.0001, ###, p < 0.001, and ##, p < 0.01 were compared with CLP group. One-way ANOVA was done with Tukey's post hoc test.
| Hippocampus |
Prefrontal cortex |
|||||
|---|---|---|---|---|---|---|
| Sham | CLP | CLP + RAGEab | Sham | CLP | CLP + RAGEab | |
| RAGE | 1 ± 0.44 | 28.5 ± 5.29**** | 2.54 ± 1.37#### | 1 ± 1.02 | 35.39 ± 11.7**** | 4.25 ± 2.51#### |
| Iba-1 | 1 ± 0.51 | 28.2 ± 2.02**** | 7.64 ± 1.82#### | 1 ± 0.97 | 4.97 ± 2.39** | 1.39 ± 0.67## |
| GFAP | 1 ± 0.28 | 8.49 ± 2.95**** | 1.58 ± 0.14#### | 1 ± 0.48 | 17.9 ± 6.34**** | 2.15 ± 0.68#### |
| Aβ | 1 ± 0.30 | 53.08 ± 10.91** | 17.63 ± 5.18#### | 1 ± 0.98 | 28.17 ± 13.83*** | 10.12 ± 5.01## |
| p-Tau | 1 ± 0.14 | 6.08 ± 1.45** | 2.97 ± 0.85### | 1 ± 0.57 | 0.99 ± 0.64 | 0.65 ± 0.38 |
| NeuN | 1 ± 0.10 | 0.53 ± 0.11**** | 1.01 ± 0.15#### | 1 ± 0.31 | 0.55 ± 0.19** | 1.18 ± 0.20### |