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. 2017 Nov 15;293(1):345–358. doi: 10.1074/jbc.M117.816884

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Figure 7. — Lack of Munc13-4 alters the ultrastructural changes associated with MC exocytosis. Peritoneal MCs fixed after exposure to PI. Sham, Munc13-4^+/+ MCs exposed to vehicle. A, representative cell profiles before and after stimulation. Scale bar = 4 μm. B, relative electron lucency of MC granules based on a 0 (black) to 255 (white) scale. n = ∼40 granules/cell, 30 cells/animal, four animals. C–F, stereological analysis of MC profiles. V_v, volume density; S_v, surface density; Hypodense, granules with relative electron lucency >150; Compound, multigranular profiles sharing a single delimiting membrane. n = 30 cells/animal, four animals. * = p < 0.001; all comparisons are to Munc13-4^+/+ unless otherwise indicated.