Figure 7.

The change of O-GalNAc glycosylation of APP and Aβ production in APP/PS1 transgenic mice with luteolin treatment. A, the O-GalNAc glycosylation of APP in extracts from brain homogenates was analyzed by immunoprecipitation (IP) of anti-APP antibody (C-T15). The mean density of Jacalin was quantified. B, soluble Aβs from brain homogenates of mice were detected by ELISA. Data are presented as a percentage of control (PBS-treated mice, 100%) and shown as mean ± S.D. (error bars) (n = 3 for Jacalin staining and n = 5 for Aβ detection). *, p < 0.05; **, p < 0.01; two-tailed Student's t test.