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. 2017 Oct 26;292(52):21417–21430. doi: 10.1074/jbc.M117.815639

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© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 7. — Proposed model for Mcm2-7 helicase loading. ORC binds to the ACS, recruiting Cdc6 and Mcm2-7/Cdt1 to form the OCCM. Cdc6 and Cdt1 are sequentially released from the OCCM (30). Prior to the loading of the second hexamer, sliding of a helicase-loading intermediate away from the B2 element occurs (illustrated as an ORC-Mcm2-7 complex). This allows space for the loading of the second Mcm2-7 hexamer, possibly involving a second ORC molecule interacting in the B2 sequence element. After recruitment of the second Mcm2-7–Cdt1 complex, release of Cdc6 followed by ORC and Cdt1 occurs (30, 46).