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. 2018 Jan 12;15:15. doi: 10.1186/s12974-018-1062-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — RPE morphological changes following sequential Aβ injections. a Sequential Aβ injections caused RPE swelling, which was quantified by RPE area measurements using a custom Photoshop algorithm identifying the stippled area of RPE pigment. b Animals receiving sequential control solution injections possessed thinner RPE layer compared to the Aβ group, indicated by the stippled area of RPE pigment. c The number of pixels is a surrogate marker for RPE area measurement, which showed about 2-fold increase in Aβ group compared to the control group. N = 3, Mann-Whitney, *p < 0.05