Fig. 6.

Caspase-3 activation in the outer retina of Aβ-stimulated eyes. a–b Immunoreactivity of active/cleaved caspase-3 was 2.5- and 4.5-fold higher in the Aβ-injected eyes for photoreceptors’ inner segments (IS) and RPE, respectively, compared to the control eyes. N = 3, Mann-Whitney, *p < 0.05. c Representative micrographs illustrated examples of the semi-quantitative grading of active caspase-3’s immunoreactivity in both Aβ-injected and control animals. Robust caspase-3 immunoreactivity in the IS was seen in the Aβ-injected retina, whereas weak and intermediate caspase-3 immunoreactivity was seen in the control eyes. ONL, outer nuclear layer; OS, outer segments. Scale bar 20 μm