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. 2018 Jan 12;18:74. doi: 10.1186/s12885-017-3930-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Ectopic expression of miR-200a promoted chemoresistance in breast cancer cell lines to multiple agents. Inhibition ratio of miR-200a and miR-Ctrl transfected MDA-MB-231 (a) and ZR-75-30 (b) after treating with chemo drugs 72 h. The drug concentrations were gemcitabine 5 μM, cis-platin 5 μM, and paclitaxel 60 nM, respectively. And the lysates were collected from MDA-MB-231(c) and ZR-75-30 (d) cells transfected with miR-200a and miR-Ctrl to analyze the activation of Caspases-3 and -7 using the Caspase GLO assay system. Data are mean ± SD of triplicate experiments. *p < 0.05; **p < 0.01