Table 5.
Top ten altered canonical pathways, sorted by − log10 (p) value via IPA
| Pathways | − Log10 (p value) | Involved molecules |
|---|---|---|
| Neuropathic pain signaling in dorsal horn neurons | 3.01 | TACR1, GRM7, KCNN3, CAMK1D, MAPK1, GPR37, BDNF, GRM3, GRIA1, CREB1, TAC1, GRIN3A |
| Cardiomyocyte differentiation via BMP receptors | 3.01 | NKX2-5, MAP3K7, SMAD6, MEF2C, BMP10 |
| cAMP-mediated signaling | 2.75 | ENPP6, ADCY2, RGS18, MAPK1, CAMK1D, PTGER3, GRM3, DUSP6, GNAI1, CHRM3, Cngb1, GRM7, FSHR, RGS10, CREB1, HTR1F, DRD3, PTGER4, PPP3CA |
| Estrogen biosynthesis | 2.64 | CYP4F8, CYP3A5, HSD17B7, CYP2C9, CYP2A6 (includes others), CYP51A1, CYP2C8 |
| PXR/RXR activation | 2.63 | CYP3A5, ABCC2, INS, CYP2C9, CYP2A6 (includes others), INSR, PAPSS2, Ins1, CYP2C8 |
| Wnt/β-catenin signaling | 2.43 | CDKN2A, GJA1, WNT3, APPL2, APC, SOX17, SOX2, FZD8, PPP2R1A, WNT7A, RARB, TLE4, MAP3K7, NR5A2, GSK3B |
| BMP signaling pathway | 2.43 | MAP2K4, NKX2-5, MAPK1, BMP8A, CREB1, MAP3K7, SMAD6, GREM1, BMP10 |
| Factors promoting cardiogenesis in vertebrates | 2.41 | FZD8, SMAD2, NKX2-5, WNT3, BMP8A, MAP3K7, MEF2C, GSK3B, BMP10, APC |
| Glutamate receptor signaling | 2.40 | GRM7, SLC1A4, GRM3, GRIA1, SLC38A1, GRIP1, GRIK2, GRIN3A |
| Human embryonic stem cell pluripotency | 2.39 | SOX2, FZD8, SMAD2, WNT7A, WNT3, BDNF, BMP8A, SMAD6, GSK3B, NGF, APC, INHBA, BMP10 |
| LPS/IL-1 mediated inhibition of RXR function | 2.37 | MAP2K4, GAL3ST2, ABCC2, CYP2C9, APOC2, NDST4, PAPSS2, IL1R2, TLR4, UST, CYP3A5, Sult1c2 (includes others), MAP3K7, NR5A2, CYP2A6 (includes others), GSTP1, MAOA, CYP2C8 |