Table 7.

Altered methylation genes mapped to the neuropathic pain signaling pathway by IPA

Symbol	Gene name	Log2-fold change	Type(s)
GRM3	Glutamate receptor, metabotropic 3	− 3.636	G-protein-coupled receptor
GRIA1	Glutamate receptor, ionotropic, AMPA 1	− 3.167	Ion channel
BDNF	Brain-derived neurotrophic factor	− 2.373	Growth factor
CREB1	cAMP-responsive element-binding protein 1	− 2.274	Transcription regulator
GRM7	Glutamate receptor, metabotropic 7	− 2.274	G-protein-coupled receptor
GRIN3A	Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	− 2.129	Ion channel
MAPK1	Mitogen-activated protein kinase 1	2.048	Kinase
TAC1	Tachykinin, precursor 1	2.408	Other
CAMK1D	Calcium/calmodulin-dependent protein kinase ID	2.855	Kinase
TACR1	Tachykinin receptor 1	2.855	G-protein-coupled receptor
KCNN3	Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	3.119	Ion channel
GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like)	3.855	G-protein-coupled receptor