Table 2.
Performance characteristics of Tetraplex system with reference to QMVR for identification of MMR-deficient CRCs in the test set
| No. of markers displaying allelic variation | The Tetraplex marker panel | |||
|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
| 4 | 88.6 (81.1–93.3) | 100 (98.2–100) | 100 (96.0–100) | 94.6 (90.9–96.9) |
| 3 | 95.2 (89.3–97.9) | 100 (98.2–100) | 100 (96.3–100) | 97.7 (94.7–99.0) |
| 2 | 96.2 (90.6–98.5) | 100 (98.2–100) | 100 (96.4–100) | 98.1 (95.3–99.3) |
| 1 | 97.1 (91.9–99.0) | 95.3 (91.5–97.4) | 91.1 (84.3–95.1) | 98.6 (95.8–99.5) |
Results are expressed as percentages (%), with 95% confidence intervals in parentheses
PPV positive predictive value, NPV negative predictive value