Table 2.
Health outcomes that have been associated with increased SSB consumption and have been studied in regard to SSB by gene interaction.
| Health outcomes | Mapped gene | rsID | Minor allele frequencya | Reference |
|---|---|---|---|---|
| Incident obesity | 32 BMI-Associated Genetic Variants | rs543874, rs1514175, rs1555543, rs2815752, rs2890652, rs887912, rs713586, rs2867125, rs13078807, rs9816226, rs13107325, rs10938397, rs4836133, rs2112347, rs987237, rs206936, rs10968576, rs3817334, rs4929949, rs10767664, rs7138803, rs4771122, rs11847697, rs10150332, rs2241423, rs7359397, rs1558902, rs12444979, rs571312, rs29941, rs3810291, rs2287019 | 0.03–0.49 | Qi et al. 2012 (26) |
| Adiposity | 30–33 BMI-Associated Genetic Variants | rs10938397, rs2815752, rs9816226, rs987237, rs7138803, rs713586, rs12444979, rs2241423, rs2287019, rs13107325, rs2112347, rs10968576, rs3810291, rs887912, rs13078807, rs11847697, rs2867125, rs571312, rs7359397, rs3817334, rs29941, rs543874, rs1514175, rs206936, rs1555543, rs1558902, rs4929949, rs10767664, rs10150332, rs4771122 | 0.04–0.48 | Qi et al. 2012 (26); Brunkwall et al. 2016 (27); Olsen et al. 2016 (28) |
| 6 Waist-circumference-Associated Loci | rs10146997, rs1121980, rs7138803, rs12970134, rs545854, rs987237 | 0.08–0.48 | Olsen et al. 2016 (28) | |
| 14 Waist:Hip Ratio-Associated Loci | rs1011731, rs10195252, rs1055144, rs1294421, rs1443512, rs2605100, rs4823006, rs6784615, rs6795735, rs6861681, rs6905288, rs718314, rs9491696, rs984222 | 0.02–0.48 | Olsen et al. 2016 (28) | |
| 33 Adiposity-Associated Loci | rs10508503, rs10838738, rs10938397, rs10968576, rs11847697, rs12444979, rs13107325, rs1424233, rs1514175, rs1555543, rs17782313, rs1805081, rs206936, rs2112347, rs2241423, rs2287019, rs2568958, rs2890652, rs29941, rs3810291, rs4712652, rs4771122, rs4929949, rs543874, rs6013029, rs6232, rs6602024, rs713586, rs7647305, rs9939609, rs10146997, rs1121980, rs7138803 | 0.04–0.48 | Olsen et al. 2016 (28) | |
| Fasting glucose | CHREBP/FGF21-Related Loci | rs10819937, rs10819931, rs174546, rs838133, rs4607517, rs1260326, rs2119026, rs1542423,rs799166, rs799168, rs799160, rs11974409, rs11920090, rs11924032, rs5438, rs3820034, rs5840, rs2954029 | 0.05–0.45 | McKeown and Dashti et al. 2017 (37) |
| Fasting insulin | ||||
| Metabolic Syndrome | APOA1 | rs670, rs5069 | 0.19–0.29 | Hosseini-Esfahani et al. 2017 (41) |
| APOC3 | rs5128 | |||
| TG | TG-associated genetic variants | rs1042034, rs4846914, rs1260326, rs2972146, rs645040, rs442177, rs9686661, rs6882076, rs2247056, rs17145738, rs11776767, rs1495741, rs12678919, rs2954029, rs2068888, rs174546, rs964184, rs11613352, rs4765127, rs2412710, rs2929282, rs1532085, rs11649653, rs3764261, rs10401969, rs439401, and rs5756931 | 0.02–0.47 | Sonestedt et al. 2015 (50) |
| HDL-C | HDL-C-associated genetic variants | rs4660293, rs1689800, rs4846914, rs1042034, rs12328675, rs2972146, rs13107325, rs6450176, rs2814944, rs605066, rs17145738, rs9987289, rs12678919, rs2293889, rs2954029, rs581080, rs1883025, rs2923084, rs3136441, rs174546, rs964184, rs7941030, rs7134375, rs11613352, rs7134594, rs4759375, rs4765127, rs1532085, rs2652834, rs3764261, rs16942887, rs2925979, rs11869286, rs4129767, rs7241918, rs12967135, rs7255436, rs737337, rs4420638, rs1800961, and rs181362 | 0.04–0.47 | Sonestedt et al. 2015 (50) |
| LDL-C | LDL-C associated genetic variants | rs12027135, rs2479409, rs629301, rs514230, rs1367117, rs4299376, rs12916, rs6882076, rs3757354, rs1800562, rs3177928, rs9488822, rs1564348, rs12670798, rs9987289, rs2081687, rs2954029, rs9411489, rs2255141, rs174546, rs964184, rs11220462, rs11065987, rs1169288, rs8017377, rs3764261, rs2000999, rs6511720, rs10401969, rs4420638, rs2902940, and rs6029526 | 0.05–0.48 | Sonestedt et al. 2015 (50) |
| Cardiovascular disease | Lipid-associated genetic variants | (all TG, HDL-C, and LDL-C associated genetic variants) | 0.02–0.48 | Sonestedt et al. 2015 (50) |
| Myocardial Infarction | Chromosome 9p21 Loci | rs4977574, rs2383206, and rs1333049 | 0.41–0.50 | Zheng et al. 2016 (51) |
| Hepatic Steatosis | PNPLA3 | rs738409 (l148M PNPLA3) | 0.48 | Nobili et al. 2014 (57) |
| Gout | SLC2A9 | rs11942223 (NZ population) | 0.09 | Batt et al. 2014 (67) |
| Uric Acid Concentration | rs6449173 (US population; surrogate marker) | 0.22 | ||
aMinor allele frequency is based on study-specific population and ancestry.
BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; NZ, New Zealand; SSB, sugar-sweetened beverages; TG, triglyceride.