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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Trauma Acute Care Surg. 2017 Dec;83(6):1053–1061. doi: 10.1097/TA.0000000000001685

Figure 2. Human neutrophil elastase delays fibrinolysis in tPA-challenged turbidity assays.

Figure 2

Panel A and B: Turbidity assay of purified system containing fibrinogen, thrombin, glu-plasminogen, tPA and -/+ HNE demonstrating significant prolongation of fibrinolysis due to HNE compared to the control group as well as increased A620-Max in the HNE group relative to control. Panel C and D: Turbidity assays of healthy human plasma (n = 6) challenged with tPA and -/+ HNE demonstrating significant prolongation of fibrinolysis due to HNE compared to the control group (representative curve in Panel C) as well as increased A620-Max in the HNE group relative to control. Results are reported as mean ± SEM on kinetic graphs of A620 vs time, and as mean ± 95% confidence intervals (CI) on scatter plots evaluating changes in Tm (ΔTm) and A620-Max (ΔA620-Max).