Figure 2.

Telomere movement at the NE during meiotic prophase. The four different movement classes are indicated as (A–D). Red dots indicate the positions of the telomeres relative to the NE. The relative direction of telomeric movements is indicated by black arrows. (A) Telomeres scattering in the nucleus move to the NE at the onset of leptotene stage. (B) Telomeres are tethered to the NE and stably connected to it at the late leptotene stage. The telomere clustering starts in the late leptotene stage, always overlaps with the zygotene stage and usually persists until pachytene. (C) The tightest clustering of telomeres is usually observed at the zygotene stage. (D) At pachytene, telomeres are motile and scattered over the NE again, while additional nuclear deformations and rotations occur (black arrows). For further information please see the Scherthan (2007).