Table 2.

Members and functions of the KASH protein family.

Members	Functions	References
Mammals
Syne-1 (Nesprin-1) Syne-2 (Nesprin-2)	Attach nuclei to actin filaments; nuclear migration and nucleokinesis	Apel et al., 2000; Zhang et al., 2007, 2009
Nesprin-3	A versatile connector between the nucleus and the cytoskeleton	Ketema and Sonnenberg, 2011
Nesprin-4	Binding kinesin; cell polarization	Roux et al., 2009
KASH 5	Dynein-driven telomere dynamics in meiosis	Morimoto et al., 2012
Drosophila
Klarsicht	Anchoring microtubules to the NE; nuclear migration and centrosome attachment	Mosleybishop et al., 1999; Patterson et al., 2004; Elhananytamir et al., 2012
MSP-300	Nuclear anchorage	Yu et al., 2006
C. elegans
KDP-1	Cell- cycle progression	Mcgee et al., 2009
ANC-1	Nuclear anchorage	Starr and Han, 2002
UNC-83	Nuclear migration	Starr et al., 2001; Meyerzon et al., 2009
ZYG-12	Links centrosomes to nuclei; meiotic chromosome paring and synapsis	Malone et al., 2003; Sato et al., 2009; Zhou et al., 2009
S. pombe
Kms1	Meiotic dynein-driven chromosome movement and pairing	Miki et al., 2004; Chikashige et al., 2006
Kms2	Meiotic and mitotic chromosome movements	Miki et al., 2004; Chikashige et al., 2006; King et al., 2008
S. cerevisiae
Csm4	Meiotic actin-driven chromosome movements and pairing	Conrad et al., 2008; Koszul et al., 2008
Dictyostelium
Interaptin	Function unknown	Rivero et al., 1998
Arabidopsis
WIP1-3	Anchors WIT1-2 to the NE; anchoring RanGAP to the NE	Yu et al., 2011; Zhou et al., 2012b, 2015b
SINE1	Actin-dependent nuclear positioning	Zhou et al., 2014
SINE2	Contributes to innate immunity against an oomycete pathogen	Zhou et al., 2014
AtTIK	Function unknown	Graumann et al., 2014