Table 4.
Quorum-repressed genes.
| Locus taga | Namea | Annotationa | Early stationary phase fold changeb | |||
|---|---|---|---|---|---|---|
| QS | qteE | qslA | qteE qslA | |||
| PA0045 | hypothetical protein | −2.2 | NC | −2.9 | −3.3 | |
| PA0047 | hypothetical protein | −2.3 | NC | −1.9 | −2.3 | |
| PA0592 | ksgA | rRNA (adenine-N6,N6)-dimethyltransferase | −1.6 | NC | NC | −1.4 |
| PA0944 | purN | phosphoribosylaminoimidazole synthetase | −1.8 | NC | NC | NC |
| PA1302 | probable heme utilization protein precursor (hxuC) | −2.1 | NC | NC | NC | |
| PA1303 | signal peptidase | −2.4 | NC | NC | NC | |
| PA1542 | hypothetical protein | −1.8 | NC | 1.7 | 1.9 | |
| PA1580 | gltA | citrate synthase (cisY) | −1.6 | NC | NC | NC |
| PA1595 | hypothetical protein | −1.9 | NC | NC | NC | |
| PA1757 | thrH | homoserine kinase | −2.0 | NC | NC | NC |
| PA1791 | hypothetical protein | −1.9 | NC | −2.1 | −3.1 | |
| PA2583 | probable sensor/response regulator hybrid | −1.7 | NC | NC | NC | |
| PA2665 | fhpR | Transcriptional activator of P. aeruginosa flavohemoglobin, FhpR (ygaA) | −1.7 | NC | NC | NC |
| PA2770 | hypothetical protein | −1.7 | NC | NC | 2.3 | |
| PA2780 | bswR | bacterial swarming regulator BswR | −1.5 | NC | NC | NC |
| PA2930 | probable transcriptional regulator | −2.4 | NC | NC | NC | |
| PA2950 | pfm | proton motive force protein, PMF | −1.6 | NC | NC | NC |
| PA2964 | pabC | 4-amino-4-deoxychorismate lyase | −1.5 | NC | NC | NC |
| PA2970 | rpmF | 50S ribosomal protein L32 | −2.1 | NC | NC | NC |
| PA2998 | nqrB | Na+-translocating NADH:ubiquinone oxidoreductase subunit Nrq2 | −1.8 | NC | NC | NC |
| PA3079 | hypothetical protein | −1.9 | NC | NC | NC | |
| PA3111 | folC | folylpolyglutamate synthetase | −1.6 | NC | NC | NC |
| PA3174 | probable transcriptional regulator | −1.9 | −2.3 | −2.7 | −3.2 | |
| PA3268 | probable TonB–dependent receptor | −3.4 | NC | NC | NC | |
| PA3284 | hypothetical protein | −3.3 | −5.5 | −7.4 | −8.8 | |
| PA3362 | hypothetical protein (amiS) | −2.3 | 8.0 | 12.4 | 7.3 | |
| PA3473 | hypothetical protein | −1.7 | NC | NC | NC | |
| PA3609 | potC | polyamine transport protein PotC | −2.0 | NC | NC | NC |
| PA3820 | secF | secretion protein SecF | −2.5 | NC | NC | NC |
| PA3823 | tgt | queuine tRNA-ribosyltransferase | −1.8 | NC | NC | −1.8 |
| PA3827 | lptG | Lipopolysaccharide export system permease protein LptG (yjgQ) | −1.5 | NC | NC | NC |
| PA3979 | hypothetical protein | −1.6 | NC | NC | NC | |
| PA4045 | conserved hypothetical protein (btuF; yadT) | −1.7 | NC | NC | NC | |
| PA4046 | hypothetical protein | −1.5 | NC | NC | NC | |
| PA4375 | mexW | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexW | −1.7 | NC | NC | NC |
| PA4479 | mreD | rod shape-determining protein MreD | −2.8 | NC | NC | NC |
| PA4519 | speC | ornithine decarboxylase | −1.8 | 1.9 | 2 | 3.2 |
| PA4562 | conserved hypothetical protein (mviN) | −1.7 | NC | NC | NC | |
| PA4569 | ispB | octaprenyl-diphosphate synthase (cel) | −1.8 | NC | NC | −1.9 |
| PA4628 | lysP | lysine-specific permease | −1.7 | NC | NC | NC |
| PA4630 | hypothetical protein | −2.0 | −1.6 | −2.6 | −2.5 | |
| PA4672 | peptidyl-tRNA hydrolase (pth) | −2.1 | NC | NC | NC | |
| PA4757 | conserved hypothetical protein (yeaS) | −1.5 | NC | NC | −1.4 | |
| PA4840 | conserved hypothetical protein (yciH) | −1.6 | NC | NC | NC | |
| PA5072 | probable chemotaxis transducer | −1.5 | NC | NC | NC | |
| PA5081 | hypothetical protein | −2.0 | −1.8 | NC | −1.5 | |
| PA5117 | typA | regulatory protein TypA (bipA) | −1.7 | NC | NC | NC |
| PA5139 | hypothetical protein | −2.2 | NC | NC | −3.3 | |
| PA5156 | hypothetical protein | −1.8 | NC | NC | NC | |
| PA5167 | dctP | DctP | −3.9 | NC | NC | NC |
| PA5168 | dctQ | DctQ | −4.3 | NC | NC | NC |
| PA5169 | dctM | DctM | −4.9 | NC | NC | NC |
| PA5194 | hypothetical protein | −1.7 | NC | NC | NC | |
| PA5250 | conserved hypothetical protein | −1.7 | NC | NC | NC | |
| PA5251 | hypothetical protein | −1.7 | NC | NC | NC | |
| PA5320 | coaC | Phosphopantothenoylcysteine synthase/(R)-4′-phospho-N-pantothenoylcysteine decarboxylase (coaB; coaBCI; dfp) | −1.4 | NC | NC | −1.3 |
| PA5361 | phoR | two-component sensor PhoR | −1.6 | NC | NC | NC |
| PA5492 | conserved hypothetical protein (ysxC; yihA) | −1.9 | NC | NC | NC | |
| PA5560 | atpB | ATP synthase A chain (papD, uncB) | −1.8 | NC | NC | −2.4 |
Locus tags, gene names, and gene annotations from the Pseudomonas Genome Database (http://www.pseudomonas.com).
QS represents the WT vs. lasR rhlR comparison, while all anti-activator mutant comparisons are vs. the wild-type. BOLD denotes genes of the quorum-repressed regulon in early stationary phase also differentially expressed in log phase. Negative values indicate repression, positive values indicate activation. NC, no change.