Table 5.
Serum creatinine concentrations after transplantation in renal graft recipients stratified according to the FCN2 rs17549193 C>T, FCN2 rs4521835 T>G, and FCN2 rs7851696 G>T gene polymorphism genotypes
| Time after Tx (month) | rs17549193:C>T FCN2 genotype | rs4521835:T>G FCN2 genotype | rs7851696:G > T FCN2 genotype | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | TT + CT vs CC | TT | TG | GG | GG + TG vs TT | GG | GT | TT | TT + GT vs GG | |
| Mean ± SD | Mean ± SD | Mean ± SD | p | Mean ± SD | Mean ± SD | Mean ± SD | p | Mean ± SD | Mean ± SD | Mean ± SD | p | |
| Creatinine (mg/dL) | ||||||||||||
| 1 | 1.84 ± 0.95 | 1.85 ± 0.71 | 1.79 ± 0.56 | 0.11 | 1.76 ± 0.81 | 1.91 ± 0.75 | 1.81 ± 0.99 | 0.06 | 1.80 ± 0.70 | 1.78 ± 0.82 | 3.38 ± 2.39 | 0.82 |
| 3 | 1.72 ± 0.60 | 1.78 ± 0.58 | 1.81 ± 0.59 | 0.12 | 1.65 ± 0.55 | 1.88 ± 0.63 | 1.68 ± 0.54 | 0.04* | 1.74 ± 0.56 | 1.77 ± 0.65 | 2.02 ± 0.81 | 0.85 |
| 6 | 1.72 ± 0.66 | 1.80 ± 0.57 | 1.81 ± 0.60 | 0.07 | 1.66 ± 0.53 | 1.89 ± 0.70 | 1.68 ± 0.52 | 0.03* | 1.75 ± 0.58 | 1.71 ± 0.52 | 2.52 ± 1.78 | 0.96 |
| 12 | 1.69 ± 0.56 | 1.82 ± 0.64 | 1.73 ± 0.54 | 0.08 | 1.66 ± 0.51 | 1.87 ± 0.65 | 1.67 ± 0.55 | 0.08 | 1.75 ± 0.59 | 1.67 ± 0.56 | 2.32 ± 0.89 | 0.65 |
| 24 | 1.73 ± 0.60 | 1.71 ± 0.49 | 1.79 ± 0.56 | 0.65 | 1.70 ± 0.58 | 1.79 ± 0.54 | 1.67 ± 0.53 | 0.36 | 1.74 ± 0.55 | 1.65 ± 0.58 | 2.09 ± 0.42 | 0.38 |
| 36 | 1.73 ± 0.66 | 1.70 ± 0.52 | 1.76 ± 0.54 | 0.66 | 1.69 ± 0.64 | 1.76 ± 0.57 | 1.69 ± 0.57 | 0.25 | 1.72 ± 0.60 | 1.66 ± 0.55 | 2.31 ± 0.85 | 0.98 |
| 48 | 1.73 ± 0.68 | 1.80 ± 0.60 | 1.73 ± 0.53 | 0.19 | 1.67 ± 0.62 | 1.85 ± 0.65 | 1.71 ± 0.63 | 0.08 | 1.75 ± 0.61 | 1.79 ± 0.72 | 1.76 ± 0.54 | 0.90 |
| 60 | 1.74 ± 0.73 | 1.69 ± 0.55 | 1.77 ± 0.57 | 0.56 | 1.76 ± 0.74 | 1.75 ± 0.64 | 1.59 ± 0.47 | 0.97 | 1.74 ± 0.65 | 1.64 ± 0.64 | 1.80 ± 0.62 | 0.37 |
p value was calculated with the Mann–Whitney test
SD standard deviation, FCN2 ficolin-2 gene, OR odds ratio; 95% CI 95% confidence interval
* p < 0.05