Table 1.
List of studies performed by using PBMCs and T cells as model systems.
| Omics | Study | Cell type | References | Identifiers and other data sources |
|---|---|---|---|---|
| Transcriptomics | Systemic lupus erythematosus | PBMCs | Bennett et al., 2003; Chaussabel et al., 2008; Fernandez et al., 2009; Smiljanovic et al., 2012; Kröger et al., 2016 | [–, GEO: GSE11909, GSE13887, GSE38351, –] |
| Dermatomyositis | PBMCs | Greenberg et al., 2005 | [GEO: GSE1551] | |
| Acute multiple sclerosis | PBMCs | Achiron et al., 2007 | – | |
| Rheumatoid arthritis | PBMCs | Edwards et al., 2007; Teixeira et al., 2009 | [–, GEO: GSE15573] | |
| T1DM | PBMCs | Wang et al., 2008; Levy et al., 2012 | [–, GEO: GSE35725] | |
| Multiple types of Diabetes | PBMCs | Collares et al., 2013 | – | |
| HIV | PBMCs | Zhang et al., 2013 | – | |
| COPD | PBMCs | Bahr et al., 2013 | [GEO: GSE42057] | |
| Pancreatic cancer | PBMCs | Baine et al., 2011 | – | |
| Renal cell carcinoma | PBMCs | Twine et al., 2003; Burczynski et al., 2005 | – | |
| – | T cells | Ciofani et al., 2012; Hu et al., 2013 | [GEO: GSE40918, GSE48138] | |
| – | Th1 & Th2 | Kanduri et al., 2015 | [GEO: GSE71646] | |
| – | Th17 | Tuomela et al., 2016 | [GEO: GSE52260] | |
| Epigenomics | – | T cells (Naïve CD4+) | Tuomela and Lahesmaa, 2013; Chen et al., 2016 | – |
| Proteomics | Kidney transplant (biopsies) | PBMCs | Savaryn et al., 2016 | – |
| Inflammation | PBMCs | Haudek-Prinz et al., 2012 | – | |
| – | T cells | Filén et al., 2009 | – | |
| – | Th1 | Rosengren et al., 2005; Pagani et al., 2015 | [–, PRIDE: PXD001066] | |
| – | Th1 & Th2 | Loyet et al., 2005 | – | |
| Metabolomics | Schizophrenia and depression | PBMCs | Liu et al., 2015 | – |
| – | PBMCs | Kew et al., 2003 | – | |
| – | T cells | Geiger et al., 2016; Angelin et al., 2017; Mak et al., 2017 | – |
In case of meta-analysis (Kröger et al., 2016) all the datasets recruited in the study are also cited and their corresponding data identifiers and references are added. Symbol “—“ denotes no data identifier mapped to public repositories. GEO stands for Gene Expression Omnibus and PRIDE stands for PRoteomics IDEntifications database.