Table 2.
Sample demographic and clinical characteristics.
| Variable | Total sample | Cognitively healthy at follow-up | EarlyMCI at follow-up | p-value |
|---|---|---|---|---|
| n | 264 | 200 | 64 | |
| eMCI cognitive status at first speech sample | 20 | 28 | ||
| Age at first speech sample | 61.8 (6.5) | 61.1 (6.5) | 64.2 (5.9) | 0.04 |
| Age at second speech sample | 64.2 (6.6) | 63.6 (6.7) | 66.3 (5.9) | 0.04 |
| Sex (n; %F) | 180; 67.4% | 141; 70% | 36; 56% | 0.03 |
| Education (y) | 16.4 (2.8) | 16.5 (2.7) | 16.0 (2.8) | 0.13 |
| WRAT-III standard score | 106.7 (9.3) | 106.7 (8.9) | 106.7 (10.3) | 0.52 |
| APOE ε4 allele (n; %ε4 +) | 104; 39% | 80; 40% | 22; 34% | 0.49 |
| Parental history of AD (n; %+) | 213; 79.8% | 159; 80% | 52; 81% | 0.83 |
| Ethnicity (n; % white) | 252; 95.8% | 194; 97% | 58; 91% | |
| CES-D | 6.6 (0.49) | 5.2 (0.77) | 0.83 | |
| Self-reported hearing loss (n; %+) | 9; 3% | 7; 4% | 2; 3% | 0.80 |
eMCI, early Mild Cognitive Impairment; F/M, female/male; WRAT-III, Wide Range Achievement Test – Third Edition, reading subtest; APOE, apolipoprotein E; AD, Alzheimer’s disease; CES-D, Clinical Evaluation Scale of Depression, MMSE, Mini-Mental State Examination; RAVLT, Rey Auditory Verbal Learning Test, Total score. Items in bold indicate statistically significant difference between CH and eMCI at p < 0.05.