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. 2018 Jan 9;8:959. doi: 10.3389/fphar.2017.00959

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Copyright © 2018 Li, Gao, Tang, Liu, Wu, Qu, Long, Li, Liu, Liu, Yuan, Mao, Liu, Zheng, Wang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oral administration of sulforaphene (LFS-01) reverses dextran sodium sulfate (DSS)-induced colitis in model mice. Oral treatment of LFS-01 was assessed by (A) survival rate; (B) change of original weight; (C) DAI score. (D,E) The colon length was determined after sacrifice. (F) H&E-stained results for the sections of mouse colon. (G) Histopathological analysis for the H&E-stained sections. (H) The MPO activity of colonic tissue was detected by ELISA following the manufacturer’s protocol. All data were evaluated as mean ± SEM (n = 7). Statistical analysis of the quantitative multiple group comparisons was performed using the one-way analysis of variance (ANOVA) followed by Tukey’s test, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.