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. 2018 Jan 9;8:959. doi: 10.3389/fphar.2017.00959

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Copyright © 2018 Li, Gao, Tang, Liu, Wu, Qu, Long, Li, Liu, Liu, Yuan, Mao, Liu, Zheng, Wang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Water-soluble formulation CD-LFS-01 (also named as Cyclone-01) exhibited superior protective effects on colitis mice than 5-ASA. (A) Molecular model of LFS-01 encapsulated in α-Cyclodextrin (α-CD) and CD-LFS-01 contained in a vial (in powder and dissolved in 0.5 ml water, respectively). (B) The scanning electron microscopy (SEM) data for water-soluble formulation CD-LFS-01. The clinical outcome of CD-LFS-01 in DSS-induced colitis model was assessed by (C) survival rate; (D) change of original weight and (E) DAI score; (F) the colon length was determined after sacrifice. (G) The sections of mouse colon was H&E-stained (Magnification, 200×). (H) Histopathologic analysis was performed in the H&E-stained sections. (I) Colon length in different groups. All data were evaluated as mean ± SEM (n = 7). Statistical analysis of the quantitative multiple group comparisons was performed using the one-way analysis of variance (ANOVA) followed by Tukey’s test, ^∗p < 0.05, ^∗∗∗p < 0.001, n.s., not significant.