Table 2.
Significant activations in control subjects, in schizophrenia patients and in relatives of schizophrenia patients during the context phase of the irony tasks.
| Region | Control group | Schizophrenic group | Relative group | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hem | x | y | z | Zmax | Voxel | Hem | x | y | z | Zmax | Voxel | Hem | x | y | z | Zmax | Voxel | |
| CONTEXT PHASE (WITHIN-GROUP ACTIVATIONS) | ||||||||||||||||||
| SFG/DLPFC | R | 36 | 40 | 38 | 3.88 | 734 | L | −38 | 42 | 34 | 4.1 | 1,558 | ||||||
| Paracingulate Gyrus | R | 4 | 14 | 44 | 4.21 | 1,083 | ||||||||||||
| MTG posterior division | R | 50 | −36 | 0 | 5.06 | 888 | ||||||||||||
| Posterior Cingulum | L | −4 | −16 | 42 | 5.57 | 359 | ||||||||||||
| IPL | R | 60 | −14 | 26 | 3.63 | 827 | ||||||||||||
| IPL | L | −38 | −34 | 40 | 5.17 | 11,829 | ||||||||||||
| TPJ | L | −42 | −54 | 18 | 4.82 | |||||||||||||
| Insula | L | −32 | 26 | 2 | 4.81 | |||||||||||||
| Precuneus | L | −2 | −60 | 40 | 3.97 | 1,112 | L | −12 | −52 | 34 | 5.7 | 12,639 | ||||||
| STG posterior division | L | −48 | −42 | 6 | 5.15 | |||||||||||||
| TPJ | L | −58 | −50 | 16 | 5.14 | |||||||||||||
| MTG posterior division | L | −60 | −30 | −4 | 5.13 | |||||||||||||
| Posterior Cingulum | L | −4 | −50 | 32 | 4.89 | |||||||||||||
| TPJ | L | −58 | −52 | 24 | 4.75 | 972 | ||||||||||||
| TPJ | R | 44 | −48 | 18 | 4.09 | 368 | ||||||||||||
| Insula | R | 34 | 20 | 12 | 3.89 | 931 | ||||||||||||
| Thalamus | L | −8 | −14 | −4 | 3.51 | 333 | ||||||||||||
| Schizophrenic group > Control group | Relative group > Control group | |||||||||||||||||
| CONTEXT PHASE (BETWEEN-GROUP ACTIVATIONS) | ||||||||||||||||||
| SFG/DLPFC | R | 40 | 46 | 22 | 3.73 | 714 | L | −42 | 40 | 30 | 3.59 | 469 | ||||||
| IFG (pars triangularis) | L | −50 | 40 | 2 | 4.42 | 456 | ||||||||||||
| IFG (pars opercularis) | L | −42 | 12 | 24 | 4.15 | 1,320 | ||||||||||||
| MFG/DLFC | R | 52 | 8 | 38 | 3.43 | 520 | ||||||||||||
| IPL | R | 60 | −14 | 26 | 3.56 | 528 | ||||||||||||
| IPL | L | −44 | −46 | 46 | 4.21 | 1,132 | ||||||||||||
During the context phase, we found significant between-group activations only in the SG>CG and in the RG>CG.
x, y, z coordinates are in millimeters, Montreal Neurological Institute (MNI) system.
Selected local maxima are shown. Z (Gaussianised T/F) statistic images were threshold using clusters determined by Z > 2.3 and a (corrected) cluster significance threshold of P = 0.05. In case of the larger clusters (5,000–13,000 voxels) we listed the output of the cluster breakdown as well.
BA, Brodmann area; Hem, hemisphere; Voxel, number of voxels; L, left; R, right; SFG, Superior Frontal Gyrus; DLPFC, Dorsolateral Prefrontal Cortex; MFG, Middle Frontal Gyrus; DLFC, Dorsolateral Frontal Cortex; IFG, Inferior Frontal Gyrus; STG, Superior Temporal Gyrus; MTG, Middle Temporal Gyrus; TPJ, Temporo-parietal Junction; IPL, Inferior Parietal Lobule.