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. 2018 Jan 9;8:2634. doi: 10.3389/fmicb.2017.02634

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Copyright © 2018 Rausch, Sztuba-Solinska and Le Grice.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PAN RNA secondary structures and potential KSHV protein binding sites. Models generated from SHAPE-MaP experiments using PAN RNA isolated from (A) nuclei, (B) cytoplasm or (C) virions. The MRE core motif and poly-A tail are indicated in all panels, while Domains I-III are common to all three panels but are indicated only in panel (A). Orange zones reflect differences in reactivity calculated for RNA probed in- or ex-vivo that are consistent with protein binding. Adapted from Sztuba-Solinska et al. (2017).