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. 2018 Jan 9;8:2634. doi: 10.3389/fmicb.2017.02634

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Copyright © 2018 Rausch, Sztuba-Solinska and Le Grice.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Secondary structure of the EBOV minigenome determined by CE-SHAPE. Predicted base pairing of 3′ leader and 5′ trailer sequences is shown together with a heat shock protein A 8 (HSPA 8) binding site. The discontinuity created by omission of the GFP gene from the displayed minigenome construct sequence is also indicated. Nucleotide shading is in proportion to normalized reactivity. Adapted from Sztuba-Solinska et al. (2016).