Table 3. Local graph theory metrics for first-group nodes (“non-classical” OCD brain regions).

Brain Region	Node	MNI coordinates			OCD	HC	Pa
		x	y	z
					Local clustering coefficient
Right frontal pole	66	19.4	62.8	-7.4	8.5±2.3	6.4±1.7	0.003
Left frontal pole	80	-20.5	61.6	-7.3	8.9±2.0	7.0±1.8	0.005
Right frontal pole	54	15.7	46.6	40.4	8.6±2.2	7.0±2.0	0.019
Left frontal pole	73	-15.5	53.6	30.4	8.1±1.8	7.0±1.8	0.073
Right frontal pole/middle frontal gyrus	47	37.4	38.5	29.8	8.3±1.9	7.1±1.4	0.033
Left frontal pole/middle frontal gyrus	2	-37.6	37.4	28.0	8.1±2.4	7.2±1.8	0.212
Right frontal pole	8	21.0	59.6	18.6	7.5±1.4	7.1±2.0	0.490
Left frontal pole	56	-34.9	38.9	-14.3	8.3±2.3	6.7±1.2	0.012
Left frontal pole	25	-39.7	47.0	7.6	7.6±1.7	7.2±1.4	0.472
Midline frontal pole	97	-3.1	63.8	7.2	7.1±2.0	7.2±2.5	0.929
Midline supplementary motor cortex	88	1.2	-1.7	61.0	8.4±1.9	6.7±1.5	0.003
Right post-central+precentral gyrus	71	48.0	-13.5	46.8	8.1±2.4	7.4±1.4	0.216
Left post-central+precentral gyrus	57	-45.2	-15.8	49.3	7.8±1.8	7.3±1.5	0.391
Right post-central+precentral gyrus	34b	59.2	-3.2	21.1	9.4±2.5	7.7±2.1	0.050
Left post-central+precentral gyrus	45	-58.4	-9.2	23.9	9.5±2.4	8.4±2.4	0.192
Left post-central+precentral gyrus	100	-25.5	-26.5	68.9	9.5±2.6	7.6±1.4	0.010
					Local betweenness centrality
Right frontal pole	66b	19.4	62.8	-7.4	934±923	2067±1662	0.019
Left frontal pole	80b	-20.5	61.6	-7.3	477±862	1048±969	0.014
Right frontal pole	54	15.7	46.6	40.4	662±757	1201±923	0.059
Left frontal pole	73	-15.5	53.6	30.4	547±557	1113±1133	0.066
Right frontal pole/middle frontal gyrus	47	37.4	38.5	29.8	929±727	1257±1100	0.292
Left frontal pole/middle frontal gyrus	2	-37.6	37.4	28.0	853±845	959±1099	0.748
Right frontal pole	8	21.0	59.6	18.6	1103±1362	1544±1603	0.369
Left frontal pole	56	-34.9	38.9	-14.3	668±657	1834±1469	0.004
Left frontal pole	25	-39.7	47.0	7.6	1421±1489	1183±1013	0.560
Midline frontal pole	97	-3.1	63.8	7.2	1980±1972	1412±1274	0.291
Midline supplementary motor cortex	88b	1.2	-1.7	61.0	942±872	2004±1926	0.083
Right post-central+precentral gyrus	71	48.0	-13.5	46.8	1392±1515	1225±1544	0.735
Left post-central+precentral gyrus	57	-45.2	-15.8	49.3	1577±1595	1469±1437	0.829
Right post-central+precentral gyrus	34b	59.2	-3.2	21.1	470±525	1172±1142	0.024
Left post-central+precentral gyrus	45	-58.4	-9.2	23.9	441±525	525±710	0.280
Left post-central+precentral gyrus	100	-25.5	-26.5	68.9	288±418	710±718	0.039

OCD, Obsessive-compulsive disorder; HC, Healthy control.; MNI, Montréal Neurological Institute.

Endpoint values are subject group- AUC means ± standard deviation.

Note that node-generation does not always produce laterally symmetric brain node pairs.

^aP value for T-test corrected for multiple comparisons with false discovery rate (FDR).

^bVariable with non-normal distribution; data rank-transformed and tested non-parametrically.

Significant findings in bold.