Table 4. Local graph theory metrics for second-group nodes (“classical” OCD brain regions).

Brain Region	Node	MNI coordinates			OCD	HC	Pa
		x	y	z
					Local clustering coefficient
Left orbitofrontal/subgenual cingulate	67	-7.5	20.5	-16.5	7.7±2.7	8.6±3.4	0.445
Right orbitofrontal cortex	78	18.6	21.0	-19.0	8.0±3.1	7.3±2.4	0.454
Right orbitofrontal cortex	20	36.9	42.8	-13.0	7.6±2.0	7.0±1.6	0.306
Right caudate	30	13.3	12.4	4.9	7.3±1.5	7.0±2.0	0.677
Left caudate/accumbens/putamen	98	-15.1	11.2	3.2	8.0±2.4	7.9±2.2	0.946
Midline posterior middle cingulate	69	0.4	8.6	39.4	7.8±1.4	7.0±1.9	0.163
Midline pregenual anterior cingulate	59	0.5	45.2	3.6	8.0±2.7	7.2±1.8	0.302
Midline anterior middle cingulate	95	0.4	34.0	26.8	7.1±1.8	6.0±1.9	0.098
					Local betweenness centrality
Left orbitofrontal/subgenual cingulate	67	-7.5	20.5	-16.5	633±1021	655±883	0.950
Right orbitofrontal cortex	78	18.6	21.0	-19.0	1296±1492	561±468	0.075
Right orbitofrontal cortex	20	36.9	42.8	-13.0	1062±1493	1144±1154	0.850
Right caudate	30	13.3	12.4	4.9	1286±1571	1130±1125	0.734
Left caudate/accumbens/putamen	98	-15.1	11.2	3.2	862±996	370±353	0.062
Midline posterior middle cingulate	69	0.4	8.6	39.4	1597±1253	1350±1582	0.593
Midline pregenual anterior cingulate	59	0.5	45.2	3.6	1320±1243	703±740	0.069
Midline anterior middle cingulate	95	0.4	34.0	26.8	2209±2294	2257±3141	0.958

OCD, Obsessive-compulsive disorder; HC, Healthy control.; MNI, Montréal Neurological Institute.

Endpoint values are subject group- AUC means ± standard deviation.

Note that node-generation does not always produce laterally symmetric brain node pairs.

^aP value obtained with T-test corrected for multiple comparisons with false discovery rate (FDR).

No significant effects of diagnosis in this node group.

In a third group of all remaining nodes in the brain (77), there were also no significant effects of diagnosis.