Table 4. Allele frequencies at candidate sites under selection in human gamete-recognition genes.

Entries on the left show frequencies for ancestral and derived alleles (ancestral alleles listed first) in four continental population groups in the 1000 Genomes Phase 1 release. Entries on the right show the minor allele frequency (MAF) summed over all populations, and the number of nonsynonymous SNPs in a 90.3 Mbp interval on the same chromosome that had a MAF greater than or equal to the candidate site (relative to N, the total number of nonsynonymous SNPS in parentheses). The significance of the MAF is characterized by P (the proportion of N with a MAF greater than or equal to the MAF for the candidate site).

Candidate site		Population group				MAF	SNPs (N)≥MAF	P
		Africa	Americas	Asia	Europe
C4BPA 300, rs4844573	ACT Thr	0.815	0.431	0.327	0.367	0.467	19 (1,408)	0.013
	ATT Ile	0.185	0.569	0.673	0.633
ZP3 315, rs2906999	CCG Pro	0.589	0.522	0.477	0.461
	TCG Ser	0.411	0.478	0.523	0.538	0.495	1 (740)	0.0014
ZP2 36, rs2075520	GTG Val	0.648	0.356	0.460	0.273	0.420	61 (1,445)	0.042
	GGG Gly	0.352	0.644	0.540	0.727