Table 3.

Multivariate analysis of adjusted risk for PlEf development by dose metric parameter.

Variable	Hazard ratio (95% CI)
Lung V60	1.04 (0.97–1.11)
Lung V50	1.10 (1.02–1.17)
Lung V40	1.12 (1.05–1.18)
Lung V30	1.12 (1.05–1.19)
Lung V20	1.10 (1.04–1.15)
Lung V10	1.06 (1.02–1.10)
Lung V5	1.05 (1.02–1.08)
Mean lung dose	1.26 (1.12–1.41)
Heart V60	1.03 (0.99–1.06)
Heart V50	1.03 (1.004–1.05)
Heart V40	1.02 (1.002–1.04)
Heart V30	1.01 (1.0–1.03)
Heart V20	1.02 (1.003–1.03)
Heart V10	1.02 (1.004–1.03)
Heart V5	1.02 (1.01–1.03)
Mean heart dose	1.03 (1.01–1.06)

Models included one dosimetric parameter, pleural involvement of the tumor, and tumor volume. Each dose metric parameter was tested (one at a time) in a multivariate model adjusted for pleural involvement of the tumor and tumor volume.

PlEf: pleural effusion.

^*p-Value based on Cox Proportional Hazard Model.