Table 1. Variants that exhibit genome-wide significant and suggestive evidence of linkage to myopia from the collapsed haplotype pattern linkage analysis.
| CHR | HLOD | ALPHA | LOD | POS | GENE |
|---|---|---|---|---|---|
| 10q26.13 | 3.73 | 1.00 | 3.73 | 146.7658 | TACC2 |
| 10q26.2 | 2.77 | 1.00 | 2.77 | 156.932 | DOCK1 |
| 15q13.3 | 2.64 | 0.87 | 2.42 | 27.82131 | RYR3 |
| 9q31.3 | 2.58 | 1.00 | 2.58 | 117.7108 | SVEP1 |
| 9q33.2 | 2.53 | 1.00 | 2.53 | 131.6962 | CDK5RAP2 |
| 1p13.1 | 2.49 | 1.00 | 2.49 | 40.94913 | IGSF21 |
| 10q25.3 | 2.41 | 1.00 | 2.41 | 133.0324 | VWA2 |
| 10q24.31 | 2.34 | 1.00 | 2.34 | 119.6265 | CWF19L1 |
| 10q26.11 | 2.15 | 1.00 | 2.15 | 141.0359 | EIF3A |
| 10q24.2 | 2.08 | 1.00 | 2.08 | 119.2729 | ABCC2 |
| 15q15.2 | 2.04 | 1.00 | 2.04 | 42.58454 | STARD9 |
| 12q24.13 | 2.03 | 1.00 | 2.03 | 129.8192 | CCDC42B |
| 1p31.3 | 1.98 | 1.00 | 1.98 | 94.08912 | INADL |
| 11q22.3 | 1.97 | 1.00 | 1.97 | 113.0644 | EXPH5 |
| 12q23.2 | 1.94 | 1.00 | 1.94 | 117.4295 | IGF1 |
| 12q24.13 | 1.94 | 1.00 | 1.94 | 129.8897 | IQCD |
| 6q15 | 1.92 | 1.00 | 1.92 | 99.52311 | GABRR1 |
Table displaying the genome-wide significant and suggestive linkage signals from the collapsed haplotype pattern (CHP) variant two-point linkage analysis sorted by heterogeneity LOD (HLOD). CHP variants are multi-allelic pseudo-markers corresponding to a gene and created from SNPs with a MAF <0.15. The genome-wide significance threshold is 3.3 and the genome-wide suggestive threshold is 1.9, as recommended by Lander and Kruglyak. CHR=chromosomal region, HLOD=heterogeneity LOD score of the marker, ALPHA=estimated proportion of informative families showing evidence of linkage for each HLOD, LOD=cumulative LOD across all families, POS=position in cM of the gene, GENE=Gene location of the CHP marker.