Table 2. SNPs with genome-wide suggestive evidence of linkage from multipoint analysis.
CHR | HLOD | rsID | POS | MAF | FUNCTION | GENE |
---|---|---|---|---|---|---|
9q33.1 |
3.14 |
rs1158810 |
121,809,519 |
0.4631 |
intergenic |
TLR4,BRINP1 |
9q33.1 |
3.07 |
rs1009470 |
122,289,187 |
0.4688 |
intergenic |
BRINP1,MIR147A |
9q33.1 |
2.97 |
rs16909449 |
122,861,297 |
0.4799 |
intergenic |
BRINP1,MIR147A |
9q33.2 |
2.78 |
rs17611 |
123,769,200 |
0.4927 |
exonic |
C5 |
9q33.1 |
2.71 |
rs1927321 |
121,066,417 |
0.4765 |
intergenic |
TLR4,BRINP1 |
9q33.2 |
2.67 |
rs7871736 |
124,650,611 |
0.4052 |
intronic |
TTLL11 |
9q33.3 |
2.48 |
rs4838334 |
128,843,105 |
0.4248 |
intergenic |
PBX3,LOC101929116 |
10q26.11 |
2.35 |
rs7099523 |
120,493,700 |
0.4998 |
intronic |
CACUL1 |
10q26.12 |
2.33 |
rs746832 |
122,348,065 |
0.4615 |
ncRNA_intronic |
MIR5694 |
10q26.11 |
2.31 |
rs185020036 |
120,095,773 |
0.0061 |
exonic |
FAM204A |
9q33.2 |
2.30 |
rs1536929 |
125,391,369 |
0.4291 |
exonic |
OR1B1 |
9q33.3 |
2.24 |
rs10987504 |
129,613,454 |
0.466 |
intergenic |
ZBTB43),ZBTB34 |
10q26.11 |
2.24 |
rs1419138 |
119,731,281 |
0.4295 |
intergenic |
EMX2,RAB11FIP2 |
10q26.12 |
2.22 |
rs2289337 |
122,649,482 |
0.1519 |
exonic |
WDR11 |
10q26.11 |
2.14 |
rs1925283 |
119,533,345 |
0.4789 |
intergenic |
EMX2),RAB11FIP2 |
10q26.12 |
2.10 |
rs4752384 |
121,871,353 |
0.3317 |
intergenic |
MIR4682,PPAPDC1A |
10q26.13 |
2.07 |
rs11598592 |
123,043,389 |
0.4611 |
intergenic |
MIR5694),FGFR2 |
9q33.3 |
2.05 |
rs4130590 |
130,107,964 |
0.4424 |
intronic |
GARNL3 |
9q33.1 |
2.02 |
rs10817896 |
119,232,655 |
0.4729 |
intronic |
ASTN2 |
10q26.13 |
2.00 |
rs2672592 |
124,230,750 |
0.4857 |
intronic |
HTRA1 |
9q34.11 |
1.93 |
rs2275260 |
131,285,955 |
0.4639 |
exonic |
GLE1 |
10q26.13 | 1.89 | rs2981579 | 123,337,335 | 0.4623 | intronic | FGFR2 |
Table displaying the genome-wide significant and suggestive signals from the multipoint linkage analysis sorted by HLOD. The genome-wide significance threshold is 3.3 and the genome-wide suggestive threshold is 1.9, as recommended by Lander and Kruglyak. CHR=chromosomal region, HLOD=heterogeneity LOD score, POS=position in basepairs of each SNP, MAF=minor allele frequency as calculated from the data set, FUNCTION=functional annotation of the SNP, GENE=genic location of the SNP or closest genes in the case of intergenic SNPs. Annotations performed by ANNOVAR.